Department of Anaesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Henan University People's Hospital, Zhengzhou, Henan, 450000, China. zhoujun@zzu.edu.cn.
2 papers in the library · 45 citations · publishing 2003-2026
MDMA abuse is associated with oxidative stress and potential free radical damage. Compared with 120 healthy volunteers, 120 MDMA abusers had significantly higher levels of lipoperoxide in erythrocytes and significantly lower levels of vitamin C, vitamin E, and beta-carotene in plasma, as well as lower activities of superoxide dismutase and catalase in erythrocytes. Higher MDMA dose and longer abuse duration correlated with greater increases in lipoperoxide and greater decreases in antioxidants and antioxidant enzymes. These results suggest that MDMA abuse may induce oxidative stress.
A single intravenous dose of esketamine (0.25 mg/kg) given at the start of surgery reduces postoperative anxiety in adolescents aged 13–18 years, with lower anxiety scores on days 1, 3, 7, and 14 after surgery. Depression scores were lower only on day 14. The drug did not significantly change inflammatory markers (CRP and IL-6) or cause more adverse events than placebo. Esketamine was a protective factor against postoperative anxiety (odds ratio 0.38). The findings suggest a safe, short-term benefit for anxiety, with limited effect on depression, in this age group.