Ibogaine Induces Cardiotoxic Necrosis in Rats-The Role of Redox Processes.
International journal of molecular sciences June 13, 2024 Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al. 6 citations
Ibogaine, an alkaloid used in alternative addiction treatment, caused dose-dependent heart muscle cell death (necrosis) in rats 6 and 24 hours after a single oral dose of 1 or 20 mg/kg. This cardiotoxicity was not driven by inflammation. No consistent changes in antioxidant defenses or oxidative damage markers were observed, leaving the role of oxidative stress in ibogaine-induced heart damage unclear. The findings help explain the often-fatal cardiac side effects seen in humans using ibogaine, but definitive conclusions about redox processes require further study.