Life (Basel, Switzerland)
December 23, 2021
Nikola Tatalović, Teodora Vidonja Uzelac, Milica Mijović et al.
8 citations
In female rats, ibogaine treatment produced lower liver glycogen breakdown than previously seen in males, along with dilation of liver blood vessels and increased thiol concentrations six hours after dosing. After 24 hours, liver catalase activity and lipid peroxidation rose while xanthine oxidase activity fell. Kidneys showed mild damage, decreased glutathione reductase, and increased catalase and xanthine oxidase activity at various time points. Ibogaine did not alter antioxidant enzymes in red blood cells. Bioavailability of ibogaine was two to three times higher in females than males. Effects were sex- and tissue-specific, and also dose- and time-dependent.
International journal of molecular sciences
June 13, 2024
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al.
6 citations
Ibogaine, an alkaloid used in alternative addiction treatment, caused dose-dependent heart muscle cell death (necrosis) in rats 6 and 24 hours after a single oral dose of 1 or 20 mg/kg. This cardiotoxicity was not driven by inflammation. No consistent changes in antioxidant defenses or oxidative damage markers were observed, leaving the role of oxidative stress in ibogaine-induced heart damage unclear. The findings help explain the often-fatal cardiac side effects seen in humans using ibogaine, but definitive conclusions about redox processes require further study.
Antioxidants (Basel, Switzerland)
November 9, 2021
Nikola Tatalović, Teodora Vidonja Uzelac, Zorana Oreščanin Dušić et al.
5 citations
A single dose of ibogaine (28.8 μmol/L) applied to isolated rat uterus altered contractility and antioxidant enzyme activity over four hours. In spontaneously contracting uteri, ibogaine immediately increased contraction amplitude and frequency, effects blocked by propranolol (β-adrenoceptor antagonist) and glibenclamide (KATP channel inhibitor, for frequency only). In calcium-stimulated uteri, ibogaine decreased amplitude and frequency after four hours; propranolol prevented the amplitude reduction, but glibenclamide had no effect. Ibogaine reduced superoxide dismutase 1 (SOD1) activity and increased catalase (CAT) activity after two hours in both uterus types, and in calcium-stimulated uteri also reduced SOD2 activity. After four hours, SOD1 returned to baseline while glutathione peroxidase (GSH-Px) activity rose. Pre-treatment with propranolol or glibenclamide abolished these enzyme changes, indicating ibogaine's pro-antioxidant effects are mediated by β-adrenergic receptors and KATP channels.