Life (Basel, Switzerland)
December 23, 2021
Nikola Tatalović, Teodora Vidonja Uzelac, Milica Mijović et al.
8 citations
In female rats, ibogaine treatment produced lower liver glycogen breakdown than previously seen in males, along with dilation of liver blood vessels and increased thiol concentrations six hours after dosing. After 24 hours, liver catalase activity and lipid peroxidation rose while xanthine oxidase activity fell. Kidneys showed mild damage, decreased glutathione reductase, and increased catalase and xanthine oxidase activity at various time points. Ibogaine did not alter antioxidant enzymes in red blood cells. Bioavailability of ibogaine was two to three times higher in females than males. Effects were sex- and tissue-specific, and also dose- and time-dependent.
Archives of Biological Sciences
December 5, 2018
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al.
7 citations
A single oral dose of ibogaine (1 or 20 mg/kg body weight) in rats did not alter the activities of superoxide dismutases, catalase, glutathione peroxidase, glutathione reductase, or glutathione-S-transferase in the liver or erythrocytes at 6 or 24 hours after administration. However, hepatic xanthine oxidase activity increased in rats receiving 20 mg/kg, indicating faster adenosine turnover. TBARS concentration rose in the 1 mg/kg group after 24 hours, suggesting mild oxidative stress. Histological examination revealed glycogenolytic activity in hepatocytes, peaking at 24 hours in the higher-dose group. Ibogaine influenced hepatic redox homeostasis but not enough to remodel antioxidant enzyme activities within the timeframe studied.
International journal of molecular sciences
June 13, 2024
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al.
6 citations
Ibogaine, an alkaloid used in alternative addiction treatment, caused dose-dependent heart muscle cell death (necrosis) in rats 6 and 24 hours after a single oral dose of 1 or 20 mg/kg. This cardiotoxicity was not driven by inflammation. No consistent changes in antioxidant defenses or oxidative damage markers were observed, leaving the role of oxidative stress in ibogaine-induced heart damage unclear. The findings help explain the often-fatal cardiac side effects seen in humans using ibogaine, but definitive conclusions about redox processes require further study.
Archives of Biological Sciences
January 1, 2019
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al.
4 citations
A single oral dose of ibogaine (1 or 20 mg/kg body weight) in rats altered kidney antioxidant enzyme activities and caused mild morphological changes without affecting overall kidney function. The lower dose increased superoxide dismutase 1 activity and decreased glutathione reductase activity at 6 and 24 hours; the higher dose also decreased glutathione reductase activity, indicating disrupted redox balance. After 24 hours, moderate structural changes in kidney tissue were observed, but urinalyses showed no impairment of kidney function. The authors advise monitoring kidney function during and after ibogaine use in humans.