Main targets of ibogaine and noribogaine associated with its putative anti-addictive effects: A mechanistic overview.
Journal of psychopharmacology (Oxford, England) December 1, 2023 Genís Ona, Ingrid Reverte, Giordano N Rossi et al. 20 citations
Ibogaine and its main metabolite, noribogaine, modulate several brain targets associated with substance use disorders. Rather than having a single key mechanism, their anti-addictive action appears to arise from a complex modulation of multiple receptor systems, creating potential beneficial synergies. This understanding comes from a review of theoretical and experimental studies published up to July 2022. The authors suggest that future research should apply polypharmacology approaches to better describe the multifaceted patterns of this multi-target drug, which could guide both mechanistic and therapeutic studies.