Ibogaine and Subjective Experience: Transformative States and Psychopharmacotherapy in the Treatment of Opioid Use Disorder.
Journal of psychoactive drugs January 1, 2019 Thomas K Brown, Geoff E Noller, Julie O Denenberg 48 citations
Ibogaine, a powerful oneiric alkaloid derived from Tabernanthe iboga, produces subjective experiences that may contribute to its therapeutic capacity for opioid use disorder. In 44 participants from two observational treatment studies, 43% achieved a "complete mystical experience" in more than five of seven domains on the States of Consciousness Questionnaire. Qualitative analysis revealed themes of auditory and visual phenomena, cyclic visions, confronting realizations of remorse and regret, and release from guilt and worthlessness. Many reported spiritual transformation. The oneiric effects appear to be a discrete element in ibogaine's healing capacity, distinct from its pharmacological actions that reduce withdrawal and craving.