Forensic toxicology
January 1, 2017
Luciano Chaves Arantes, Ettore Ferrari Júnior, Luciano Figueiredo De Souza et al.
50 citations
A new potent serotonin 5-HT2A receptor agonist, 25I-NBOH, was identified in blotter papers by several state-level forensic laboratories in Brazil. The molecule is labile and fragments into 2C-I during routine GC screening, requiring GC-MS, LC-QTOF-MS, FTIR, and NMR for full characterization. Individual doses range from 300 to 1000 μg. Although it is a potent 5-HT2A receptor agonist, 25I-NBOH is not registered with the UNODC and is controlled only in Sweden and Brazil. This is the first scientific report of 25I-NBOH identification in actual seizures.
Journal of Forensic Sciences
August 6, 2012
Wanderson Romão, Bruno Duarte Sabino, Maria Izabel M. S. Bueno et al.
24 citations
Forensic identification of LSD typically relies on the Ehrlich spot test, which is nonspecific and cannot distinguish LSD from the uncontrolled substance 9,10-dihydro-LSD, recently found in Brazilian blotters. This work used easy ambient sonic-spray ionization mass spectrometry (EASI-MS) to characterize LSD and 9,10-dihydro-LSD directly from blotter surfaces. Of 41 blotters analyzed by EASI-MS, 28 tested positive for LSD, seven for 9,10-dihydro-LSD, and six for neither. Results were confirmed by high-performance liquid chromatography. Combining thin-layer chromatography with EASI-MS proved a simple, powerful screening tool for forensic drug analysis.
Forensic Toxicology
July 1, 2017
José Coelho Neto, Ana Flávia B. Andrade, Rogério Araújo Lordeiro et al.
25I-NBOH, a novel psychoactive substance found on blotter paper in Brazil, can be misidentified as 2C-I by routine gas chromatography–mass spectrometry (GC–MS) because it degrades into 2C-I inside the injector unless a derivatization procedure is used. A slight adjustment to the standard GC–MS method—shortening the solvent delay window—enables detection of an additional early chromatographic peak from the degradation, allowing distinction between 25I-NBOH and 2C-I without derivatization and preventing misidentification.