Determination of "new psychoactive substances" in postmortem matrices using microwave derivatization and gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences May 1, 2016 Cláudia Margalho, Alice Castanheira, Francisco Corte Real et al. 33 citations
A validated analytical method using gas chromatography-mass spectrometry with microwave fast derivatization can detect and quantify 14 psychoactive substances—including synthetic cathinones and phenethylamines—in low volumes of vitreous humor, pericardial fluid, and whole blood. The method showed linear results between 5 and 600 ng/mL, with high precision and accuracy, and extraction efficiencies ranging from 76.6% to 112.8%. It was successfully applied to authentic forensic samples in Portugal.