Journal of analytical toxicology
October 1, 2007
Maria Del Mar Ramirez Fernandez, Marleen Laloup, Michelle Wood et al.
47 citations
A method for simultaneously measuring multiple hallucinogens, chlorpheniramine, ketamine, ritalinic acid, and several metabolites in human urine was developed and validated. The procedure uses solid-phase extraction followed by liquid chromatography-tandem mass spectrometry, with all drugs eluting within 14 minutes. Using 500 microliters of urine, limits of quantification ranged from 0.05 ng/mL for LSD to 10 ng/mL for other hallucinogens, with linear or quadratic regression from each compound's limit up to 500 ng/mL. Precision and accuracy were acceptable, and processed samples remained stable in the autosampler for at least 24 hours. The method was successfully applied to authentic urine samples containing chlorpheniramine, ketamine, LSD, and psilocin.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
May 1, 2016
Cláudia Margalho, Alice Castanheira, Francisco Corte Real et al.
33 citations
A validated analytical method using gas chromatography-mass spectrometry with microwave fast derivatization can detect and quantify 14 psychoactive substances—including synthetic cathinones and phenethylamines—in low volumes of vitreous humor, pericardial fluid, and whole blood. The method showed linear results between 5 and 600 ng/mL, with high precision and accuracy, and extraction efficiencies ranging from 76.6% to 112.8%. It was successfully applied to authentic forensic samples in Portugal.
Bioanalysis
July 1, 2016
Cláudia Margalho, Francisco Corte-Real, Manuel López-rivadulla et al.
The main psychoactive component of Salvia divinorum, salvinorin A, can be identified and quantified in biological specimens, which is important for forensic and clinical toxicology. Despite research efforts, uncontrolled abuse of the substance has increased, posing serious short- and long-term health risks. Alternative biological matrices, such as those used as complementary postmortem samples or when blood and urine are unavailable, can provide useful information about prior exposure. This article summarizes legal aspects of Salvia divinorum and salvinorin A, along with analytical methods for determining salvinorin A in biological matrices.