The serotonergic hallucinogen 5-methoxy-N,N-dimethyltryptamine disrupts cortical activity in a regionally-selective manner via 5-HT(1A) and 5-HT(2A) receptors.
Neuropharmacology February 1, 2016 Maurizio S Riga, Analia Bortolozzi, Letizia Campa et al. 33 citations
The hallucinogen 5-MeO-DMT reduces low-frequency cortical oscillations (<4 Hz) in the prefrontal cortex, visual cortex, somatosensory cortex, and auditory cortex of anesthetized mice. In the prefrontal cortex, this reduction occurs via 5-HT(1A) receptors, as it persists in 5-HT(2A) receptor knockout mice and is blocked by a 5-HT(1A) antagonist. In sensory areas, the effect in visual cortex also involves 5-HT(1A) receptors, while other regions require 5-HT(2A) receptors. Antipsychotic drugs reverse these disruptions, supporting the model's use for developing new treatments.