The international journal of neuropsychopharmacology
August 1, 2014
Maurizio S Riga, Guadalupe Soria, Raúl Tudela et al.
75 citations
5-MeO-DMT, a natural hallucinogen found in ayahuasca, disrupts brain activity in the medial prefrontal cortex (mPFC) of rodents, increasing firing in 51% and decreasing it in 35% of pyramidal neurons, while reducing the power of low-frequency cortical oscillations (<4 Hz) by 31%. This effect, which depends on 5-HT1A and 5-HT2A receptor activation, resembles disruptions caused by other psychotomimetic agents like phencyclidine and DOI. Antipsychotic drugs (haloperidol, clozapine, risperidone) and an mGlu2/3 agonist reversed the oscillation reduction. 5-MeO-DMT also decreased blood-oxygen level dependent (BOLD) responses in visual cortex and mPFC. The findings suggest these cortical alterations underlie hallucinogenic effects and may aid antipsychotic drug development.
Neuropharmacology
November 1, 2018
Maurizio S Riga, Laia Lladó-Pelfort, Francesc Artigas et al.
57 citations
The hallucinogen 5-MeO-DMT alters brain oscillations more in cortical areas than in the thalamus, particularly increasing delta power in the visual cortex of mice lacking 5-HT2A receptors. It also boosts beta-band coherence between the prefrontal cortex, visual cortex, and mediodorsal thalamus. Blocking 5-HT1A receptors with WAY-100635 prevented most of these oscillatory changes in knockout mice, suggesting 5-HT1A antagonists could help treat visual hallucinations. Effects on prefrontal theta activity and cortico-thalamic coherence may relate to antidepressant properties.
Neuropharmacology
February 1, 2016
Maurizio S Riga, Analia Bortolozzi, Letizia Campa et al.
33 citations
The hallucinogen 5-MeO-DMT reduces low-frequency cortical oscillations (<4 Hz) in the prefrontal cortex, visual cortex, somatosensory cortex, and auditory cortex of anesthetized mice. In the prefrontal cortex, this reduction occurs via 5-HT(1A) receptors, as it persists in 5-HT(2A) receptor knockout mice and is blocked by a 5-HT(1A) antagonist. In sensory areas, the effect in visual cortex also involves 5-HT(1A) receptors, while other regions require 5-HT(2A) receptors. Antipsychotic drugs reverse these disruptions, supporting the model's use for developing new treatments.
eLife
January 5, 2024
Daniel Toker, Eli Müller, Hiroyuki Miyamoto et al.
21 citations
Bidirectional communication between the cortex and thalamus via a specific cross-frequency channel is linked to conscious states. In humans, mice, and rats, low-frequency waves (1–13 Hz) sent from either the cortex or thalamus are consistently encoded by the other region using high gamma waves (52–104 Hz). This cross-frequency communication is diminished during propofol-induced unconsciousness and generalized spike-and-wave seizures, but enhanced by the psychedelic 5-MeO-DMT. Numerical simulations and neural recordings suggest these changes are mediated by shifts in thalamocortical electrodynamics toward or away from edge-of-chaos criticality, offering a mathematical framework for disrupted information transfer during unconsciousness.