National Institutes of Health
2 papers in the library · 77 citations · publishing 2011-2014
Psychopharmacology July 2, 2014 Theresa M. Carbonaro, Amy J. Eshleman, Michael J. Forster et al. 67 citations
No Summary
Pharmacology, biochemistry, and behavior September 1, 2011 J C Winter, D J Amorosi, Kenner C Rice et al. 10 citations
In mice genetically modified to express human CYP2D6 (Tg-CYP2D6) and wild-type mice, the psychedelic 5-MeO-DMT produced similar rates of learning a drug discrimination task. Bufotenine did not substitute for 5-MeO-DMT, while its lipid-soluble analog acetylbufotenine produced intermediate substitution. Combining harmaline with 5-MeO-DMT significantly increased drug-appropriate responding in both mouse types, indicating harmaline enhances 5-MeO-DMT's stimulus effects. Harmaline alone also produced significant 5-MeO-DMT-appropriate responding in Tg-CYP2D6 mice, suggesting metabolic interactions. No differences between wild-type and Tg-CYP2D6 mice were found in acquisition or responses to bufotenine and acetylbufotenine.