University of North Texas
4 papers in the library · 119 citations · publishing 2011-2023
Psychopharmacology July 2, 2014 Theresa M. Carbonaro, Amy J. Eshleman, Michael J. Forster et al. 67 citations
No Summary
Journal of Pharmacology and Experimental Therapeutics April 8, 2011 Michael B. Gatch, Michael J. Forster, Aaron Janowsky et al. 42 citations
Three synthetic hallucinogens—DIPT, 5-MeO-DET, and 5-MeO-AMT—produced behavioral effects in rats similar to those of known abused hallucinogens like LSD and DMT, but not to psychostimulants like cocaine or methamphetamine. DIPT fully substituted for DMT and DOM, while 5-MeO-DET fully substituted for DMT; none fully substituted for cocaine or methamphetamine. All three compounds acted at serotonin 5-HT(1A) and 5-HT(2A) receptors and blocked serotonin reuptake. 5-MeO-AMT also weakly released serotonin and blocked dopamine uptake. DIPT and 5-MeO-DET may have abuse liability similar to hallucinogens and were hazardous at high doses, causing activity and lethality.
Behavioural Pharmacology June 1, 2020 Michael B. Gatch, Sean B. Dolan, Michael J. Forster 6 citations
Most synthetic cathinones tested produce effects similar to the club drug MDMA in rats, but not all. In rats trained to distinguish MDMA from a placebo, six of seven cathinones—4-fluoromethcathinone, 4-methylmethcathinone, 4-methylethcathinone, 3-fluoromethcathinone, pentedrone, and ethylone—fully substituted for MDMA's discriminative stimulus effects. Methcathinone produced at most 43% MDMA-like responding, and higher doses suppressed responding. The potency of MDMA-like versus psychostimulant-like effects varied substantially among compounds, indicating that some synthetic cathinones are more MDMA-like than psychostimulant-like. This variability suggests that cathinones with MDMA-like effects may be more likely used as club drugs.
Drug and Alcohol Dependence Reports August 10, 2023 Rebecca D. Hill, Ritu A. Shetty, Nathalie Sumien et al. 4 citations
Three synthetic benzofurans—5-APDB, 5-MAPB, and 6-APB—were tested in mice and rats to compare their behavioral effects with MDMA, cocaine, and methamphetamine. In mice, 6-APB produced strong locomotor stimulation 20 to 50 minutes after injection, while 5-MAPB caused modest stimulation, and 5-APDB initially depressed then modestly stimulated activity. All three compounds were more potent than MDMA. In rats trained to discriminate MDMA from saline, all three benzofurans fully substituted for MDMA, indicating similar subjective effects. Only 5-MAPB fully substituted for cocaine, and none fully substituted for methamphetamine. The findings suggest these benzofurans may have abuse liability as substitutes for MDMA.