Lasting effect of psilocybin on sociability can be blocked by DNA methyltransferase inhibition
bioRxiv (Cold Spring Harbor Laboratory) March 11, 2025 Chenchen Song, Tinya Chang, Tobias Buchborn et al. 4 citations preprint
A single dose of the psychedelic psilocybin lastingly improves social behavior in a mouse model of autism (Cntnap2-knockout mice). This effect is blocked by inhibiting DNA methyltransferase I, suggesting an epigenetic mechanism involving DNA methylation underlies psilocybin's long-term influence on social function.