Analysis of 4-bromo-2,5-dimethoxyphenethylamine abuser's urine: identification and quantitation of urinary metabolites.
Journal of forensic sciences January 1, 2013 Tatsuyuki Kanamori, Kyoko Nagasawa, Kenji Kuwayama et al. 20 citations
The main breakdown product of the hallucinogenic drug 2C-B in human urine is 4-bromo-2,5-dimethoxyphenylacetic acid, accounting for 73% of detected metabolites. Two other metabolites, 4-bromo-2-hydroxy-5-methoxyphenylacetic acid and 4-bromo-2,5-dimethoxyphenylethyl alcohol, made up 13% and 4.5% respectively. In contrast, the primary metabolites reported in rat urine were different compounds and appeared only in small amounts in humans, indicating species-specific differences in how 2C-B is processed. The most abundant human metabolite likely forms through deamination by monoamine oxidase (MAO) followed by oxidation, suggesting MAO plays a crucial role in human 2C-B metabolism.