Jean-Claude Mathieu-Daudé

2 papers in the library · 65 citations · publishing 2006

Papers

Distribution of ibogaine and noribogaine in a man following a poisoning involving root bark of the Tabernanthe iboga shrub.

Journal of analytical toxicology September 1, 2006 Violeta Kontrimaviciūte, Olivier Mathieu, Jean-Claude Mathieu-Daudé et al. 38 citations

In a 48-year-old Caucasian male with a history of drug abuse who died after ingesting root bark from the shrub Tabernanthe iboga, ibogaine and its main metabolite noribogaine were found in all examined tissues except cardiac tissue. The highest concentrations appeared in spleen, liver, brain, and lung. Tissue-to-blood concentration ratios for ibogaine averaged 1.78 in spleen, 3.75 in liver, 1.16 in brain, and 4.64 in lung; for noribogaine, the ratios were 0.83, 2.43, 0.90, and 2.69, respectively. Both substances crossed the blood-brain barrier and were secreted in bile. Very low concentrations occurred in prostatic tissue.

DOI: 10.1093/jat/30.7.434 Full text Ibogaine Forensic toxicology Forensic analysis Poisoning investigation +11

Liquid chromatography-electrospray mass spectrometry determination of ibogaine and noribogaine in human plasma and whole blood. Application to a poisoning involving Tabernanthe iboga root.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences November 7, 2006 Violeta Kontrimaviciūte, Hélène Breton, Olivier Mathieu et al. 27 citations

A new laboratory method using liquid chromatography and mass spectrometry was developed to measure ibogaine and noribogaine in human plasma and whole blood. The method extracts the compounds from samples, separates them on a column, and detects them by their mass-to-charge ratios. It accurately quantifies ibogaine and noribogaine across a range of concentrations, with high precision and recovery. The drugs remain stable in frozen plasma for at least one year and in blood for up to two months at -20 degrees Celsius. The method was successfully applied to analyze a poisoning case involving Tabernanthe iboga root.

DOI: 10.1016/j.jchromb.2006.05.035 Full text Ibogaine quantification Noribogaine measurement Clinical toxicology Poisoning analysis +5