Liquid chromatography-electrospray mass spectrometry determination of ibogaine and noribogaine in human plasma and whole blood. Application to a poisoning involving Tabernanthe iboga root.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences November 7, 2006 Violeta Kontrimaviciūte, Hélène Breton, Olivier Mathieu et al. 27 citations
A new laboratory method using liquid chromatography and mass spectrometry was developed to measure ibogaine and noribogaine in human plasma and whole blood. The method extracts the compounds from samples, separates them on a column, and detects them by their mass-to-charge ratios. It accurately quantifies ibogaine and noribogaine across a range of concentrations, with high precision and recovery. The drugs remain stable in frozen plasma for at least one year and in blood for up to two months at -20 degrees Celsius. The method was successfully applied to analyze a poisoning case involving Tabernanthe iboga root.