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Masato Koreeda

3 papers in the library · 256 citations · publishing 1984-2005

Papers

Divinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint, Salvia divinorum

The Journal of Organic Chemistry November 1, 1984 Leander J. Valdés, William M. Butler, George M. Hatfield et al. 174 citations

The hallucinogenic Mexican mint Salvia divinorum contains two terpenoid compounds, divinorin A and divinorin B. Divinorin A is a psychotropic terpenoid, while divinorin B is also present. The work describes the isolation and characterization of these compounds from the plant.

DOI: 10.1021/jo00198a026 Hallucinogen Traditional medicine Terpenoid Psychology +2

Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse.

Behavioural pharmacology December 1, 2005 William E Fantegrossi, Kelly M Kugle, Leander J Valdes et al. 80 citations

Salvinorin A, a natural compound from the Mexican mint Salvia divinorum, is the first known naturally occurring kappa-opioid receptor agonist with a novel chemical structure distinct from other opioids. In mice, salvinorin A caused rapid but short-lived sedation and motor incoordination, similar to the effects of the mu-agonist remifentanil and the synthetic kappa-agonist U69,593. Using selective antagonists, the motor effects of salvinorin A and U69,593 were shown to be mediated by kappa-opioid receptors, while remifentanil's effects involved mu-receptors. Salvinorin A and U69,593 differed in their susceptibility to antagonism by nor-binaltorphamine, suggesting salvinorin A may bind to the kappa-receptor differently than traditional kappa-agonists. This raises the possibility that developing other diterpene-based opioids could yield therapeutic compounds.

DOI: 10.1097/00008877-200512000-00005 Full text Salvinorin a Natural compound Mexican mint extract Mint compound +13