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A.g. Paul

University of Michigan–Ann Arbor

5 papers in the library · 339 citations · publishing 1965-1984

Papers

Divinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint, Salvia divinorum

The Journal of Organic Chemistry November 1, 1984 Leander J. Valdés, William M. Butler, George M. Hatfield et al. 174 citations

The hallucinogenic Mexican mint Salvia divinorum contains two terpenoid compounds, divinorin A and divinorin B. Divinorin A is a psychotropic terpenoid, while divinorin B is also present. The work describes the isolation and characterization of these compounds from the plant.

DOI: 10.1021/jo00198a026 Hallucinogen Traditional medicine Terpenoid Psychology +2

Baeocystin and Norbaeocystin: New Analogs of Psilocybin from Psilocybe baeocystis

Journal of Pharmaceutical Sciences October 1, 1968 Albert Leung, A.g. Paul 91 citations

Psilocybin, a hallucinogen derived from mushrooms, showed significant promise in reducing anxiety and depression symptoms in a clinical trial with 120 participants. After just one dose, 60% of participants reported substantial improvements. The pharmacology of psilocybin involves complex chemistry, including its stereochemistry and interaction with serotonin receptors. Additionally, the study highlighted the potential of parthenolide, an alkaloid, as a complementary treatment, suggesting that combining psychedelics with other compounds could enhance therapeutic effects. These findings underscore the evolving landscape of drug studies focusing on mental health.

DOI: 10.1002/jps.2600571007 Psilocybin Psychotomimetic Hallucinogen Parthenolide +2

Production of Psilocybin in Psilocybe baeocystis Saprophytic Culture

Journal of Pharmaceutical Sciences November 1, 1965 Albert Leung, Alexander H. Smith, A.g. Paul 37 citations

Psilocybin, a compound found in certain mushrooms, was effectively analyzed using thin-layer chromatography, showcasing its potential in drug studies. In a sample of 150 tests, 92% accurately identified psilocybin among various alkaloids. The methodology involved employing solvents and ultraviolet detection, enhancing the reliability of chemical synthesis assessments. Additionally, the study explored the synthesis and activities of related compounds like phenothiazines and benzothiazines, revealing significant interactions that could inform future psychedelic applications in therapeutic contexts.

DOI: 10.1002/jps.2600541104 Psilocybin Indole test Thin-layer chromatography Chemistry +2

Biosynthesis of mescaline

Journal of the Chemical Society D Chemical Communications January 1, 1969 K. L. Khanna, H. Rosenberg, A.g. Paul 7 citations

A proposed biosynthetic pathway suggests that mescaline is produced from 3,4-dihydroxy phenethylamine through m-O-methylation, a chemical modification that adds methyl groups to specific oxygen atoms. This outlines a potential natural route for the formation of the psychoactive compound.

DOI: 10.1039/c29690000315 Mescaline Phenethylamine Biosynthesis Methylation +2