Determination of common drugs of abuse in body fluids using one isolation procedure and liquid chromatography--atmospheric-pressure chemical-ionization mass spectromery.
Journal of analytical toxicology January 1, 1998 M J Bogusz, R D Maier, K D Krüger et al. 111 citations
A single, universal solid-phase extraction method using C18 cartridges efficiently extracts a wide range of opiate agonists, cocaine metabolites, and LSD from blood, serum, urine, and other biological fluids. The method achieves high recoveries for most drugs and produces clean extracts suitable for analysis by liquid chromatography coupled with atmospheric-pressure chemical-ionization mass spectrometry. The procedure was developed for routine forensic toxicology casework and demonstrates broad applicability across different drug classes and biological matrices.