Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes.
Bioorganic & medicinal chemistry March 20, 2003 Daniele Passarella, Raffaele Favia, Alessandra Giardini et al. 23 citations
A method to synthesize 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes using cycloaddition followed by cross-coupling is described. The binding affinity of these new compounds to the receptor targets characteristic of ibogaine is reported.