A preliminary investigation of ibogaine: case reports and recommendations for further study.
Journal of substance abuse treatment January 1, 1994 S G Sheppard 162 citations
A single high dose of ibogaine, a naturally occurring psychotropic alkaloid, eliminated opiate withdrawal symptoms in seven addicted individuals. At doses of 700–1800 mg, none showed significant withdrawal after the 24–38-hour psychoactive period. Of the six who took 1000 mg or more, two relapsed after weeks, one returned to intermittent heroin use, and three remained drug-free for at least 14 weeks. The one who took 700 mg resumed abuse after 2 days. Ibogaine may help treat substance abuse and inspire future medications.