Behavioral reactivity following 5-MeODMT administration in 5,7-DHT-pretreated killer rats.
Pharmacology, biochemistry, and behavior June 1, 1990 G R Cuadra, V A Molina 4 citations
Rats classified as killers, nonkillers, or grouped received a brain injection of a chemical that destroys serotonin fibers or a placebo. After 7-10 days, all rats showed typical behaviors (forepaw treading, hindlimb abduction) when given a serotonin-like drug. Nonkiller and grouped rats with the lesion showed heightened behavioral responses, indicating supersensitivity. Killer rats with the same lesion showed a smaller increase in these behaviors. Serotonin uptake measurements confirmed that the lesion reduced serotonin uptake equally in all lesioned rats. The findings suggest that killer rats have a reduced ability to adapt their serotonin systems after damage.