Psychopharmacology
January 1, 1980
R A Glennon, R Young, J A Rosecrans et al.
46 citations
Rats can be trained to distinguish the hallucinogenic drug 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from a saline placebo using a lever-choice task. Once trained, the rats responded to 14 chemically similar tryptamine compounds as if they were 5-OMe DMT, with the strength of this response depending on the dose. For all but one compound, the dose needed to produce the drug-like response was strongly correlated (r = -0.86) with how tightly the compound binds to serotonin (5-HT) receptors, suggesting that these drugs' hallucinogenic effects are mediated through the serotonin system.
Life sciences
June 14, 1982
R Young, J A Rosecrans, R A Glennon
26 citations
Rats trained to distinguish injections of 5-OMe DMT or LSD from saline showed that the effects of these drugs are interchangeable: animals trained on one drug recognized the other. The serotonin antagonist BC-105 reduced the effects of both drugs, but the pattern of this reduction differed between them, suggesting that while both drugs act through the serotonin system, they interact with it in somewhat different ways.
Psychopharmacology
January 1, 1983
R Young, J A Rosecrans, R A Glennon
25 citations
In rats, the drug 5-OMeDMT produces discriminative effects that generalize to LSD, and both effects are blocked by the serotonin antagonist BC-105 in a dose-dependent manner. When rats responded for food under a variable-interval schedule, 1.0-3.0 mg/kg of 5-OMeDMT decreased response rates. BC-105 blocked the rate decrease from 1.5 mg/kg but not from 3.0 mg/kg, even though both doses alone reduced responding equally. These findings show that the dose of 5-OMeDMT critically determines whether antagonism occurs.
European journal of pharmacology
December 17, 1981
R A Glennon, J A Rosecrans, R Young
21 citations
Rats learned to distinguish an injection of the hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task. Once they reliably identified the drug, 36 different phenylisopropylamine compounds were tested to see if they produced similar effects. The compounds fell into three groups: those that fully mimicked 5-OMe DMT, those that partially did, and those that did not. The findings suggest that certain phenylisopropylamines, unlike amphetamine, can produce hallucinogen-like effects in rats, likely involving serotonin pathways.
Pharmacology, biochemistry, and behavior
December 1, 1986
R Young, J A Rosecrans, R A Glennon
10 citations
In rats trained to distinguish the psychedelic compound 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline, the serotonin antagonist cyproheptadine completely blocked the drug's effects at a low dose, while cinanserin and methergoline partially blocked them, and methysergide had little effect. At a higher dose of 5-OMe DMT, methysergide and methergoline partially blocked the drug's effects, but cyproheptadine and cinanserin did not. The authors advise caution when drawing conclusions from studies using these drugs until their in vivo effects and mechanisms are better understood.