Development of selective tolerance to the serotonin behavioral syndrome and suppression of locomotor activity after repeated administration of either 5-MeODMT or mCPP.
Life sciences July 1, 1985 M A Sills, I Lucki, A Frazer 54 citations
Repeated administration of a drug that activates 5-HT1A receptors in rats leads to tolerance to the behavioral effects of that same drug, but not to the effects of a drug that activates 5-HT1B receptors. Conversely, repeated administration of the 5-HT1B-activating drug produces tolerance to its own effects but not to those of the 5-HT1A-activating drug. This lack of cross-tolerance suggests that different serotonin receptor subtypes (5-HT1A and 5-HT1B) mediate different behaviors: the serotonin behavioral syndrome and suppression of locomotor activity.