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A Frazer

2 papers in the library · 145 citations · publishing 1982-1985

Papers

Prevention of the serotonin syndrome in rats by repeated administration of monoamine oxidase inhibitors but not tricyclic antidepressants.

Psychopharmacology January 1, 1982 I Lucki, A Frazer 91 citations

Repeated treatment of rats with monoamine oxidase inhibitors (nialamide, pargyline, and phenelzine) prevented the serotonin syndrome—a behavioral response to serotonin receptor activation—induced by direct-acting agonists 5-MeDMT or LSD, and also reduced 3H-serotonin binding in the brain stem and spinal cord. In contrast, repeated administration of tricyclic antidepressants (amitriptyline, desmethylimipramine, and chlorimipramine) or iprindole did not significantly affect either the syndrome or binding. Pretreatment with p-chlorophenylalanine blocked nialamide's effect on the syndrome caused by 5-MeDMT. These findings suggest that repeated monoamine oxidase inhibitor treatments may prevent the serotonin syndrome by reducing serotonin receptor binding sites in the brain stem and/or spinal cord.

DOI: 10.1007/BF00464567 Full text

Development of selective tolerance to the serotonin behavioral syndrome and suppression of locomotor activity after repeated administration of either 5-MeODMT or mCPP.

Life sciences July 1, 1985 M A Sills, I Lucki, A Frazer 54 citations

Repeated administration of a drug that activates 5-HT1A receptors in rats leads to tolerance to the behavioral effects of that same drug, but not to the effects of a drug that activates 5-HT1B receptors. Conversely, repeated administration of the 5-HT1B-activating drug produces tolerance to its own effects but not to those of the 5-HT1A-activating drug. This lack of cross-tolerance suggests that different serotonin receptor subtypes (5-HT1A and 5-HT1B) mediate different behaviors: the serotonin behavioral syndrome and suppression of locomotor activity.

DOI: 10.1016/0024-3205(85)90142-0 Full text