Increased behavioural response to 5-methoxy-N,N-dimethyltryptamine but not to RU-24969 after intraventricular 5,7-dihydroxytryptamine administration.
European journal of pharmacology September 3, 1984 A P Nisbet, C A Marsden 29 citations
Destroying serotonin-producing neurons in the brain with a chemical (5,7-DHT) made rats more sensitive to a drug that activates serotonin receptors (5-MeO-DMT). The stronger behavioral response matched how much serotonin was lost. But the same treatment did not increase the hyperactivity caused by a different drug (RU-24969) that targets a specific serotonin receptor subtype (5HT1). This suggests that different serotonin receptors control different behaviors and that losing serotonin neurons changes sensitivity to some, but not all, receptor-activating drugs.