Levels of dimethyltryptamine and O-methylbufotenine in cerebrospinal fluid were measured in people with acute schizophrenia and in surgical and neurological control groups. Some patients with schizophrenia showed higher levels of both amines than controls, but the differences in distribution were not statistically significant in the sample studied. The gas-chromatographic method used can detect these substances at the low picogram level.
Rats trained to distinguish the hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a drug discrimination task were tested with three related compounds: the 4-methoxy, 4-methylthio, and 5-methylthio derivatives of DMT. All three derivatives produced effects similar to the original drug. The relative potency of the compounds, from most to least potent, was 5-OMe DMT, followed by 5-SMe DMT, then 4-OMe DMT, and finally 4-SMe DMT.