Metabolic study of new psychoactive substance methoxpropamine in mice by UHPLC-QTOF-HRMS.
Drug testing and analysis May 1, 2023 Marta Massano, Enrico Gerace, Martina Borsari et al. 6 citations
Methoxpropamine (MXPr), a dissociative drug similar to ketamine, was studied in 16 mice to track how it breaks down in the body. After injecting the mice with 1, 3, or 10 mg/kg of MXPr, urine was collected hourly for six hours and then at 12- to 24-hour intervals; plasma was collected after 24 hours. Using high-resolution mass spectrometry, the main metabolite found in urine was desmethyl-MXPr-glucuronide, detectable up to 24 hours after administration. NorMXPr, produced by N-dealkylation, appeared in urine, plasma, and fur. Other metabolites in fur and plasma included desmethyl-MXPr and dihydro-MXPr. Understanding these metabolites can help improve toxicological screening for MXPr in biological samples.