The Therapeutic Potential of Psychedelics in Treating Substance Use Disorders: A Review of Clinical Trials
Medicina February 6, 2025 Lavinia Hogea, Dana Cătălina Tabugan, Iuliana Costea et al. 14 citations
A systematic review of 16 clinical trials from 2013 to 2023 found that psychedelic-assisted therapy, particularly with psilocybin and ayahuasca, can reduce alcohol and tobacco dependence, with psilocybin decreasing cravings and promoting long-term abstinence. Improvements in substance use reduction were significant when psychedelics were combined with psychotherapy. However, variability in dosages and study design calls for more standardized approaches. Regulatory barriers and specialized clinical training are needed to safely integrate these therapies into mainstream addiction treatment. Psychedelics offer a promising alternative for those unresponsive to conventional methods.