Human brain mapping
May 1, 2024
Saampras Ganesan, Winson F Z Yang, Avijit Chowdhury et al.
23 citations
In an adept practitioner performing jhana meditation over 5 days inside a 7 Tesla MRI scanner (27 runs), the thalamus and several cortical networks—somatomotor, limbic, default-mode, control, and temporo-parietal—showed good within-subject reliability across all jhanas. When fMRI measurements were adjusted for variability in self-reported phenomenology, other networks such as attention and salience showed noticeable increases in reliability. The findings provide a preliminary template of reliable brain areas likely underpinning core neurocognitive elements of jhana meditation and highlight the value of neurophenomenological designs for characterizing neuronal variability in advanced meditative states.
Biological psychiatry. Cognitive neuroscience and neuroimaging
April 1, 2025
Ruchika S Prakash, Anita Shankar, Vaibhav Tripathi et al.
13 citations
Network neuroscience examines brain organization by mapping connections between its elements. This review describes how mindfulness meditation may alter structural and functional brain networks. Although evidence is preliminary, studies suggest mindfulness shifts connector hubs—the anterior cingulate cortex, thalamus, and mid-insula—and reduces intraconnectivity within the default mode network. Global connectivity findings are mixed. The authors call for rigorous study designs, open science, and diverse samples to better understand mindfulness's impact on brain networks.
NeuroImage
January 1, 2025
Winson F Z Yang, Avijit Chowdhury, Terje Sparby et al.
12 citations
The stages of insight (SoI) are a series of psychological realizations experienced during advanced investigative insight meditation (AIIM). In a case study of one adept meditator who underwent 4 hours of 7T functional magnetic resonance imaging (fMRI) across 26 runs with concurrent phenomenological reports, distinct whole-brain activity patterns were identified for specific SoI, differing from non-meditative control states. SoI consistently deactivated brain regions involved in self-related processing, such as the medial prefrontal cortex and temporal poles, while activating areas linked to awareness and perception, including parietal and visual cortices, caudate, brainstem nuclei, and cerebellum. Patterns of brain activity related to affective processing and SoI phenomenology were also observed. This provides the first neurophenomenological evidence that SoI shifts and deconstructs self-related perception and conceptualization, increasing general awareness and perceptual sensitivity.
Cerebral cortex (New York, N.Y. : 1991)
February 5, 2025
Ruby M Potash, Winson F Z Yang, Brian Winston et al.
11 citations
Advanced concentrative absorption meditation produces distinct, distributed brain-wide activity patterns that differ from ordinary consciousness, as shown by ultrahigh-field 7T fMRI in a single expert meditator. Using geometric eigenmode decomposition, the study found elevated global brain state power and energy during meditation compared to control tasks, with mid-frequency brain state power and energy following a non-random, cubic trajectory across the meditation sequence. These brain state differences correlated with subjective reports of attention, meditation quality, and sensations. The findings reveal similarities and differences between advanced meditation and psychedelic-induced states, offering insights into refined conscious states and their implications for well-being.
Network neuroscience (Cambridge, Mass.)
January 1, 2025
Isaac N Treves, Winson F Z Yang, Terje Sparby et al.
6 citations
Advanced meditation involves states and stages that develop with experience. A case study using 7-T fMRI and dynamic functional connectivity analysis of a meditator practicing jhāna advanced absorptive concentration meditation (ACAM-J) identified three distinct brain states: a default-mode network (DMN)-anticorrelated state, a hyperconnected state, and a sparsely connected state. The DMN-anticorrelated state was more prevalent during ACAM-J than control conditions and increased with deeper meditation. The hyperconnected state, marked by elevated thalamocortical and somatomotor connectivity, was also more common during ACAM-J but decreased over the session, corresponding to reports of wider attention and reduced physical sensations. This suggests that functional neuroimaging can track the dynamics of altered states of consciousness in advanced meditators.
bioRxiv : the preprint server for biology
November 13, 2025
Winson F Z Yang, Ruby Potash, Grace Mackin et al.
preprint
Advanced concentration absorption meditation (ACAM-J) produces a distinct, structured mode of awareness characterized by stable positive states and reduced narrative thought. In the first ultra-high-field (7T) fMRI study of jhana meditation, neural trajectories across eight successive states showed reorganization from anterior to posterior brain regions, flattening of cortical hierarchies, and nonlinear changes in global brain harmonics. These brain changes were tightly linked to equanimity, attentional stability, and behavior. Brain activity patterns associated with ACAM-J related more to attentional monitoring than to suffering-related processes. The findings suggest advanced meditation offers a framework for understanding psychological transformation and supporting human well-being.