Use of Various Doses of S-Ketamine in Treatment of Depression and Pain in Cervical Carcinoma Patients with Mild/Moderate Depression After Laparoscopic Total Hysterectomy
Medical Science Monitor April 27, 2020 Jie Wang, Yajun Wang, Xudong Xu et al. 80 citations
High-dose S-ketamine (0.5 mg/kg) significantly reduced pain and depression scores one and three days after surgery in cervical carcinoma patients with mild to moderate depression, compared to low-dose S-ketamine, racemic ketamine, or a control. The high-dose group also showed higher serum levels of BDNF and 5-HT at those time points. However, no differences between groups remained one week after surgery. Low-dose S-ketamine (0.25 mg/kg) and racemic ketamine did not produce significant improvements. The findings suggest that subanesthetic S-ketamine offers short-term benefits for postoperative depression and pain in this population, with the higher dose being more effective than racemic ketamine.