People who use psychedelics in natural settings show weaker increases in alpha and beta brainwave power when thinking about themselves, compared to non-users, especially in regions like the posterior cingulate cortex that handle self-related information and memory. However, these differences were not replicated in a second, smaller dataset, limiting confidence in the finding. The results contribute to ongoing debate about how long psychedelic effects last in brain circuits linked to self-processing and question the specific role of default-mode network hubs in such changes.
People who have used psychedelics in naturalistic settings show weaker increases in alpha and beta brain-wave power during self-related thoughts compared to non-users, particularly in regions linked to self-processing and memory. This pattern appeared in one dataset of 70 participants but was not replicated in a second dataset of 38 participants, possibly due to the smaller sample and spatial resolution limits. The non-replicability restricts interpretation, but the work adds to understanding how psychedelic use relates to self-related thoughts and well-being, important for assessing mental health impacts.
Marijuana is one of the most popular psychoactive substances globally. Cannabis plants contain over 140 active compounds called cannabinoids, most notably THC and CBD. These cannabinoids act on the endocannabinoid system, which is crucial for maintaining bodily homeostasis and neuroplasticity. This article reviews how marijuana affects biochemical processes and electrical brain activity in animals and humans. The cited studies indicate that marijuana disrupts electrical brain activity in humans both during acute intoxication and with long-term use. Animal research helps clarify the mechanisms by which marijuana alters neuronal oscillations.