Consciousness often persists even when unresponsiveness occurs. In two experiments involving 76 healthy males, brain activity was measured during varying states of consciousness induced by propofol and dexmedetomidine (n = 39) and during sleep-deprived wakefulness and non-REM sleep (n = 37). Most participants reported internally generated experiences while unresponsive. Key brain regions, including the thalamus and cingulate cortices, were found critical for consciousness, showing consistent activity patterns regardless of anesthetic type or sleep state, highlighting a core network essential for conscious awareness.
Medical cannabis and opioids are perceived as equally effective at reducing pain intensity, but medical cannabis additionally improves emotion, functionality, and overall sense of wellbeing. A survey of Finnish chronic pain patients compared 40 medical cannabis users with 161 opioid users. After matching for confounding factors, medical cannabis users scored higher on positive emotional effects (large effect) and holistic positive effects (medium effect), with no difference in negative side effects. This supports the idea that medical cannabis alters the pain experience more holistically rather than only targeting pain intensity.