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Marcin Zawadzki

Department of Social Sciences and Infectious Diseases, Faculty of Medicine, Wroclaw University of Science and Technology, 27 Wybrzeże Wyspiańskiego, 50-370 Wrocław, Poland.

2 papers in the library · 9 citations · publishing 2024-2025

Papers

Forensic Aspects of Designer LSD Analogs Identification by GC-MS (EI) and UV Spectroscopy.

Molecules (Basel, Switzerland) December 4, 2024 Kaja Tusiewicz, Olga Wachełko, Marcin Zawadzki et al. 5 citations

Lysergic acid diethylamide (LSD) analogs, synthesized to evade drug regulations, pose challenges for forensic identification, especially their isomeric forms. Gas chromatography-mass spectrometry (GC-MS) and UV spectroscopy analyzed 13 LSD analogs. Solvents like diethyl ether, tert-butyl methyl ether, dichloromethane, and acetone provided the best sensitivity and stability, while methanol caused alcoholysis of many analogs, potentially leading to false results. Effective chromatographic separation was achieved for isomers including LSD, MiPLA, LAMPA, 1P-LSD, 1P-MiPLA, 1cP-LSD, and 1cP-MiPLA. Key mass spectrometry ions (e.g.

DOI: 10.3390/molecules29235717 Full text Forensic testing Forensic chemistry Drug testing Substance identification +7

A highly sensitive UHPLC-MS/MS method for determining 15 designer LSD analogs in biological samples with application to stability studies.

The Analyst January 13, 2025 Olga Wachełko, Karolina Nowak, Kaja Tusiewicz et al. 4 citations

A highly sensitive analytical method using UHPLC-QqQ-MS/MS can detect LSD, 13 of its designer analogs, and a metabolite at femtogram-per-milliliter levels in blood, urine, plasma, and serum. The method separates structural isomers and achieves a limit of quantification of 0.5 pg/mL for all substances. A 30-day stability study showed that collecting samples in sodium fluoride (NaF) tubes stabilizes LSD analogs and minimizes conversion of N1-substituted compounds to LSD or MiPLA. The method is the most sensitive reported for analyzing designer LSD analogs in biological samples and is suitable for routine clinical and forensic use. Fragmentation patterns from mass spectra are proposed to aid future identification of new designer LSD analogs.

DOI: 10.1039/d4an01361a Full text Psychedelics Forensics Drug detection Analytical chemistry