Yangonin, one of the kavalactones isolated from Piper methysticum G. Forst, acts through cannabinoid 1 (CB1) receptors to induce an intrathecal anti-hyperalgesia.
Journal of ethnopharmacology October 28, 2024 Lok-Hi Chow, Pin-Chen Lin, Ying-Jie Chen et al. 6 citations
Yangonin, a kavalactone from kava, reduced pain sensitivity and inflammation-induced pain in rats when injected into the spinal cord. These effects were blocked by a cannabinoid 1 (CB1) receptor antagonist, indicating yangonin acts through CB1 receptors. Yangonin did not affect nerve injury-induced pain. Kavain, another kavalactone, had no effect on any pain type tested.