Frontiers in Human Neuroscience
January 1, 2012
Gaelle Desbordes, Lobsang T. Negi, Thaddeus W. W. Pace et al.
445 citations
Eight weeks of mindfulness meditation training reduced right amygdala activation in healthy adults when viewing positive emotional images, even when they were not actively meditating. A compassion-based meditation program showed a trend toward increased right amygdala response to negative images, which correlated with lower depression scores. No changes occurred in a control group. The results suggest meditation training can alter emotional processing in the brain during ordinary, non-meditative states, indicating that such training may produce lasting, process-specific changes in mental function rather than only task-specific effects.
Focus (Am Psychiatr Publ)
January 24, 2018
Benjamin G. Shapero, Jonathan Greenberg, Paola Pedrelli et al.
165 citations
Mindfulness meditation, a practice with deep roots in eastern traditions, has gained widespread public and scientific interest. Mindfulness is a natural state of present-moment awareness, and interventions have been developed to train this skill. This review discusses the concept of mindfulness and its use in treating psychiatric disorders. It identifies which patients benefit from mindfulness-based interventions and summarizes how they work, including cognitive, psychological, and neural mechanisms that drive clinical improvements. The review offers a foundation for incorporating these interventions into clinical practice.
Psychiatry research. Neuroimaging
March 1, 2025
Michael Datko, Jacqueline Lutz, Richa Gawande et al.
1 citation
Mindfulness training for primary care patients with anxiety or depression increased activity in the dorsal medial prefrontal cortex when anticipating pain, and this brain change was strongly linked to initiating health behavior changes. Greater increases in this brain response correlated with higher levels of action plan initiation, suggesting that mindfulness strengthens emotion regulation and goal-directed behavior in the face of discomfort.
Gaelle Desbordes, Lobsang Negi
Modern neuroscience uses objective, quantitative methods to measure how mental events correspond to brain activity, while ancient contemplative traditions have relied on first-person introspective practices to understand the mind. Combining these approaches could be mutually enriching and synergistic. The scientific study of the mind would benefit greatly from including expert contemplative practitioners not only as study participants but as full co-investigators.