Less is more? A review of psilocybin microdosing
Journal of Psychopharmacology September 16, 2024 Isabella A Savides, Kim Outhoff 11 citations
A semi-structured review of psilocybin microdosing—taking sub-hallucinogenic doses of the psychedelic compound found in magic mushrooms—identified major research gaps that prevent firm conclusions about its benefits. Most available evidence comes from observational studies, while clinical and non-clinical trials remain sparse and inconsistent. The review highlights the need for more randomized placebo-controlled trials, studies of dose-response relationships, psychological and personality testing, use of active placebos, diverse study populations, psilocybin-exclusive microdosing research, and refined animal models. Definitive conclusions about efficacy remain elusive.