Lydia Fortea

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

2 papers in the library · 33 citations · publishing 2024-2025

Papers

Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine.

Molecular psychiatry April 1, 2025 Mihai Avram, Lydia Fortea, Lea Wollner et al. 26 citations

Lysergic acid diethylamide (LSD), d-amphetamine, and MDMA each reduce the integrity (within-network connectivity) of several brain networks, with LSD uniquely reducing integrity in the default-mode network. Contrary to expectations, amphetamines reduced integrity in more networks than LSD. LSD produced more pronounced decreases in between-network segregation, while amphetamines also induced increases. Seed-based connectivity mostly increased between networks across all substances, with LSD showing stronger effects than both amphetamines. All substances decreased global connectivity in visual areas, but LSD specifically increased global connectivity in the basal ganglia and thalamus. These findings clarify distinctive neurobiological effects of psychedelics and support further investigation of their therapeutic potential.

DOI: 10.1038/s41380-024-02734-y Full text Psychedelics hallucinogens Psychoactive drugs Entheogens Brain networks +5

Do classic psychedelics increase the risk of seizures? A scoping review.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology August 1, 2024 Óscar Soto-Angona, Adriana Fortea, Lydia Fortea et al. 7 citations

A scoping review of 16 human and 11 animal studies suggests that classic psychedelics may not increase seizure risk in healthy individuals or animals when used alone, but concomitant use of other substances like kambo or lithium could raise that risk. The evidence is heterogeneous and lacks sufficient external validity, so conclusions should be interpreted cautiously. The review also outlines possible neurobiological mechanisms and future research directions.

DOI: 10.1016/j.euroneuro.2024.05.002 Full text Adverse events Drug-related adverse reactions Epilepsy Hallucinogens +2