Do classic psychedelics increase the risk of seizures? A scoping review.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology August 1, 2024 Óscar Soto-Angona, Adriana Fortea, Lydia Fortea et al. 7 citations
A scoping review of 16 human and 11 animal studies suggests that classic psychedelics may not increase seizure risk in healthy individuals or animals when used alone, but concomitant use of other substances like kambo or lithium could raise that risk. The evidence is heterogeneous and lacks sufficient external validity, so conclusions should be interpreted cautiously. The review also outlines possible neurobiological mechanisms and future research directions.