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Matthew D Sacchet

Massachusetts General Hospital, Harvard Medical School, USA.

27 papers in the library · 442 citations · publishing 2012-2026

Papers

The neuroscience of highly stable, positive, and refined states of consciousness during jhana-type advanced concentration absorption meditation (ACAM-J).

bioRxiv : the preprint server for biology November 13, 2025 Winson F Z Yang, Ruby Potash, Grace Mackin et al. preprint

Advanced concentration absorption meditation (ACAM-J) produces a distinct, structured mode of awareness characterized by stable positive states and reduced narrative thought. In the first ultra-high-field (7T) fMRI study of jhana meditation, neural trajectories across eight successive states showed reorganization from anterior to posterior brain regions, flattening of cortical hierarchies, and nonlinear changes in global brain harmonics. These brain changes were tightly linked to equanimity, attentional stability, and behavior. Brain activity patterns associated with ACAM-J related more to attentional monitoring than to suffering-related processes. The findings suggest advanced meditation offers a framework for understanding psychological transformation and supporting human well-being.

Reimagining pain as an allostatic imperative: perspectives from contemplative traditions.

Neuroscience of consciousness January 1, 2025 Catherine Prueitt, Idil Sezer, Matthew D Sacchet

Pain is an allostatic imperative that commands an organism to adapt a part of its body. Drawing on empirical studies of pain reprocessing during advanced meditation, allostatic paradigms of biological self-regulation, and the philosophy of pain in the classical Sanskrit Pratyabhijñā Śaivism tradition, this paper theorizes two components of an allostatic response: homeostatic responses, which are error-corrective and aim to return to a previous stable state, and heterostatic responses, which are anticipatory and shift to a new steady state to better prepare for future challenges. Successful adaptation depends on both error-correction and anticipatory change. A broad range of affect properly accompanies pain, and the model may extend to mental pain.