A single 25-mg dose of synthetic psilocybin combined with psychological support was safe, tolerable, and acceptable for 10 adult women with anorexia nervosa or partial remission. No clinically significant changes occurred in electrocardiogram, vital signs, or suicidality. Two participants developed asymptomatic hypoglycemia that resolved within 24 hours. All adverse events were mild and transient. The findings suggest psilocybin therapy may be a promising treatment for female anorexia nervosa, a condition with no FDA-approved medications and high physiological risks.
A single 25-mg dose of synthetic psilocybin, given with psychological support, was safe and tolerable for 10 adult women with anorexia nervosa. No clinically significant changes occurred in heart health, vital signs, or suicidality. Two participants had temporary low blood sugar that resolved within a day. All side effects were mild and short-lived. Participants' reports indicated the treatment was acceptable. These results suggest psilocybin therapy may be a safe approach for female anorexia, a condition with no approved medications and high medical risk.