Healthcare policy = Politiques de sante
May 1, 2023
Sarah Kratina, Christopher Lo, Carol Strike et al.
8 citations
Canada is moving toward enabling access to therapeutic psychedelics. Federal initiatives now allow case-by-case requests for psychedelic-assisted therapies (PATs) to treat enduring and intolerable psychological suffering (EIPS) linked to life-threatening conditions. Renewed research, promising clinical trial results, public and media interest, and recognition of traditional Indigenous use have shifted the narrative around these stigmatized substances. The lack of access to PATs for EIPS, particularly at end of life, is presented as a public policy problem needing attention.
medRxiv
January 17, 2023
Ryan Yermus, Michael Verbora, Sidney H. Kennedy et al.
2 citations
preprint
Ketamine-Assisted Psychotherapy (KAP) produced large and sustained reductions in depression, anxiety, and PTSD symptoms for up to six months after treatment. In a retrospective trial of 1806 adults with treatment-resistant depression, anxiety, or PTSD, effect sizes at three months ranged from 0.75 to 0.86 and were maintained at six months (0.61 to 0.73). Between 39% and 41% of patients showed case reductions at three months, and 29% to 37% at six months. A minimal clinically important difference was reported by 50% to 75% at three months and 48% to 70% at six months. The treatment involved 4 to 6 guided ketamine sessions with psychotherapy.
October 27, 2023
Sarah Kratina, Christopher Lo, Robert Schwartz et al.
preprint
A scoping review protocol describes plans to comprehensively map the range of therapeutic psychedelic interventions reported in populations coping with life-threatening illness and end-of-life issues. The review will follow Arksey and O'Malley's framework and PRISMA-ScR guidelines to search for studies on psychedelic substances, psychological suffering, and end-of-life concerns. Data will be extracted on intervention details, participant characteristics, outcomes, theorized mechanisms, and sociocultural context. The insights aim to inform discussions about the role of psychedelic interventions for end-of-life populations.