Blotter paper labeled "1D-LSD" was seized and analyzed. Although the label suggested the compound was 1-(1,2-dimethylcyclobutane-1-carbonyl)-LSD, chemical analysis using GC/MS, LC/MS, high-resolution mass spectrometry, and NMR spectroscopy revealed the actual substance to be 1-(thiophene-2-carbonyl)-LSD, a different lysergamide. This is the first reported seizure of this compound and the first LSD analog where an aromatic carboxylic acid was condensed to LSD. The finding highlights that drug-infused blotter paper may contain substances inconsistent with their labeling, and authorities should remain vigilant for newly emerging lysergamides.
Since late 2023, a substance sold as "1D-AL-LAD" has appeared online, but chemical analysis suggests it is actually 1-(2-thienoyl)-6-allyl-nor-LSD (1T-AL-LAD), not the claimed 1-(1,2-dimethylcyclobutanecarbonyl)-6-allyl-nor-LSD. To aid forensic identification, researchers synthesized 1T-AL-LAD and characterized it with nuclear magnetic resonance spectroscopy, Fourier transform-infrared spectroscopy, liquid chromatography/high-resolution mass spectrometry, and gas chromatography/mass spectrometry. The compound was easily distinguished from previously reported lysergamides. Detectability differences in GC/MS and fragmentation patterns in LC/HRMS were noted and explained. This information will help identify the substance in seized materials should it emerge on the market.