Department of Psychiatry and Behavioral Sciences, Behavioural Biology research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 USA
57 papers in the library · 12,069 citations · publishing 2006-2025
Drug and Alcohol Dependence December 16, 2014 Theresa M. Carbonaro, Frederick S. Barrett, Matthew P. Bradstreet et al. 3 citations
No Summary
bioRxiv (Cold Spring Harbor Laboratory) March 2, 2022 Andrew Gaddis, Daniel E. Lidstone, Mary Beth Nebel et al. 2 citations preprint
Psilocybin, a classic psychedelic, alters perception and cognition by affecting connectivity between the thalamus and cortex. Using a novel analysis of resting-state fMRI data, this study found that psilocybin changes the functional organization within specific thalamic nuclei—primarily the mediodorsal and pulvinar nuclei—and alters their connections with visual and default mode networks. These changes correlated with subjective drug effects. When the thalamus was treated as a single unit, a numerical but not statistically significant increase in thalamocortical connectivity was observed, suggesting that psilocybin causes widespread modest increases offset by strong focal decreases in relevant nuclei.
PsycEXTRA Dataset January 1, 2010 Matthew W. Johnson, Roland R. Griffiths 2 citations
No Summary
June 9, 2023 Sandeep M. Nayak, Sydney White, Samantha Hilbert et al. 1 citation preprint
A longitudinal study of 657 people planning a psychedelic experience measured changes in beliefs about mind perception, metaphysical positions, and Atheist-Believer status before and after the experience. Replicating prior work, participants showed increased mind perception for living and non-living targets such as plants and animals. However, there was little to no change in metaphysical beliefs like dualism or in Atheist-Believer status. These results contrast with cross-sectional studies suggesting psychedelics alter non-naturalistic beliefs or religious identity, but they support the idea that psychedelics specifically affect how people perceive minds in various entities.
October 28, 2022 Natalie Gukasyan, Roland R. Griffiths, David B. Yaden et al. 1 citation preprint
Serotonergic antidepressants, such as SSRIs and SNRIs, weaken psilocybin's effects, while the non-serotonergic antidepressant bupropion has less of a dampening effect. In 595 reports of taking psilocybin with an antidepressant, the probability of weaker than expected effects was 0.48 for SSRIs, 0.56 for SNRIs, and 0.29 for bupropion. After discontinuing a serotonergic antidepressant, reduced psilocybin effects persisted for up to 3 months, with odds of reduced effects not significantly different from the first week until 3–6 months post-discontinuation. The findings suggest that serotonergic antidepressants diminish psilocybin's effects both concurrently and for months after stopping.
Drug and Alcohol Dependence June 7, 2014 Matthew P. Bradstreet, Matthew W. Johnson, Katherine A. Maclean et al. 1 citation
No Summary
Drug and Alcohol Dependence July 1, 2024 Alan K. Davis, Adam W. Levin, Rafael Lancelotta et al.
No Summary