A Model for the Application of Target-Controlled Intravenous Infusion for a Prolonged Immersive DMT Psychedelic Experience.
Frontiers in pharmacology January 1, 2016 Andrew R Gallimore, Rick J Strassman 51 citations
The state of consciousness induced by DMT is extraordinary, with users reporting a complete replacement of normal experience by a novel alternate universe filled with complex visual content and sentient beings. The short duration of DMT effects (under 20 minutes) limits single-dose studies. Using pharmacokinetic modeling and blood sampling data, the authors demonstrate that DMT's rapid onset and lack of acute tolerance make it suitable for target-controlled intravenous infusion, a technology used to maintain stable anesthetic levels during surgery. Simulations show this approach can induce a stable, prolonged DMT experience, enabling careful observation of psychological contents, extended accounts, functional neuroimaging, and potential psychotherapeutic applications.