Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study
Journal of Psychopharmacology January 13, 2015 Michael P. Bogenschutz, Alyssa A. Forcehimes, Jessica A. Pommy et al. 1,164 citations
In a small proof-of-concept study, ten volunteers with alcohol dependence received one or two supervised doses of psilocybin alongside therapy. Abstinence did not increase during the first four weeks of treatment but increased significantly after psilocybin administration, with gains largely maintained up to 36 weeks. The intensity of effects during the first psilocybin session strongly predicted reduced drinking and craving and increased abstinence self-efficacy in the following weeks. No serious adverse events occurred. These preliminary findings support larger controlled trials to test efficacy and mechanisms.