Phytochemical, Cytotoxicity, Antioxidant and Anti-Inflammatory Effects of Psilocybe Natalensis Magic Mushroom
Plants August 31, 2020 Sanah Malomile Nkadimeng, Alice Nabatanzi, Christiaan M.l. Steinmann et al. 66 citations
Extracts from Psilocybe natalensis, a psilocybin-containing mushroom from South Africa, show anti-inflammatory and antioxidant effects in lab tests on mouse immune cells. Boiling hot water, cold water, and ethanol extracts all reduced nitric oxide, prostaglandin E2, and interleukin 1β production in lipopolysaccharide-stimulated macrophages in a dose-dependent manner, similar to positive controls quercetin and N-nitro-L-arginine methyl ester. The extracts were safe at the concentrations used. Phytochemical analysis confirmed the presence of natural antioxidant and anti-inflammatory compounds.