Psilocybin as a treatment for anorexia nervosa: 6-week and 3-month follow-up results
Neuroscience Applied January 1, 2023 Hannah Douglass, Merle Spriggs, Kate Godfrey et al. 1 citation
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Merle Spriggs
Imperial College London
2 papers in the library · 1 citation · publishing 2023-2024
Papers
Human brain changes after first psilocybin use
October 14, 2024 Terence J. Lyons, Merle Spriggs, Leevi Kerkelä et al. preprint
A single high dose of psilocybin (25 mg) produced lasting functional and anatomical brain changes in healthy, psychedelic-naive adults, detected from one hour to one month later. Diffusion imaging showed decreased axial diffusivity in prefrontal-subcortical tracts, correlating with reduced brain network modularity, which in turn correlated with improved well-being. Increased cortical signal entropy shortly after dosing predicted better psychological well-being at one month, with next-day psychological insight mediating this relationship. No such effects occurred with a 1 mg placebo dose. Cognitive flexibility, psychological insight, and well-being also increased at one month.