Psilocybin-induced Autonomic, Perceptual, and Behavioral Change
Pharmacopsychiatry November 1, 1968 R Fischer, Diana Warshay 11 citations
In a sample of 15 college-educated volunteers, a 160 µg/kg dose of psilocybin produced measurable changes in perception and behavior. The degree of drug-induced psychological disturbance, assessed by changes in Minnesota Multiphasic Personality Inventory scores, correlated with greater variability in simple taste and vision tasks. However, the increase in pupil size, a reliable autonomic measure, showed no such relationship. The authors equate the psychological disturbance with each person's symbolic interpretation of their own central nervous system activity.